Professor Allen’s research program is dedicated to applying rigorous scientific methods to understanding vascular health, function and the atherosclerotic disease process. The work combines physiological and biochemical techniques in an attempt to better detect markers of vessel disease development and develop innovative treatments. The major focus areas are peripheral blood flow, endothelial function, and nitric oxide (NO) bioavailability.
He has been PI on National Institutes of Health funded clinical trials in both Peripheral Arterial Disease and Aging, an Australian Heart Foundation grant in Chronic Heart Failure (CHF), an American Heart Association award (basic science), as well as several smaller foundation and pharmaceutical company grants. He has also served as co-investigator on numerous grants which have generated over $14,000,000 in funding.
Recently, his group has demonstrated that in patients with peripheral arterial disease (PAD), acute inorganic nitrate supplementation increased exercise tolerance on a graded exercise test by 18%, and when subsequently administered chronically 3x a week for 12 weeks in conjunction with an exercise rehabilitation program, it produced superior benefits in pain free walking (see publications). They have also published data supporting the superiority of a novel peripherally focused exercise training regimen (PRIME) versus traditional exercise approaches in individuals under 70yr at risk for losing functional independence (see publications) and are exploring this approach in frail patients with CHF.
He is an active member of the Nitric Oxide Society and the American College of Sports Medicine.
Selected Recent Publications
Wossner, M., VanBruggen, MD., Pieper, CF., O’Reilly, E., Johnson, J. Kraus, WE., and Allen, JD. (2018). Beet the Best? Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease with Intermittent Claudication. Circulation Research, 123, 654-659. PMID: 29976553.
Allen, JD., VanBruggen, MD., Johannsen, NM., Robbins, JL., Credeur, DP., Pieper, CF., Sloane, R., Earnest, CP., Church, TS., Ravussin, E., Kraus, WE., Welsch, MA. (2018). PRIME: A Novel Low Mass, High Repetition Approach to Improve Function in Older Adults. Medicine and Science in Sports and Exercise, 50(5), 1005-1014. PMID: 29232316
Woessner, MN., McIlvenna, L., Ortiz de Zevallos, J., Neil, C., and Allen, JD. (2018). Dietary Nitrate Supplementation in Cardiovascular Health: An Ergogenic Aid or Exercise Therapeutic? Review Article. American Journal of Physiology: Heart and Circ Phyiol. 314(2), H195-H212. PMID:29101174.
Burleigh, MC., Liddle, L., Monaghan, C., Muggeridge, DJ., Sculthorpe, N., Butcher, J., Henriquez, F., Allen, JD., Easton, C. (2018). Salivary nitrite production is elevated in individuals with a higher abundance of nitrate-reducing bacteria. Free Radical Biology in Medicine, 120, 80-88. PMID:29550328
Woessner, MN., Levinger, I., Neil, C., Smith, C., and Allen, JD. (2018). Effects of Dietary Inorganic Nitrate Supplementation on Exercise Performance in Patients with Heart Failure: A Study Protocol for a Randomized, Placebo-Controlled, Cross-Over Trial. JMIR Research Protocols, 7(4), e86. PMID: 29625952